Finding a hit for a new drug target can be one of the biggest…
Category:
Key Concept
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In contrast to molecular weight and H-bond acceptor count, H-bond donor count and lipophilicity…
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IntroductoryKey Concept
Which Amino Acid is the Strongest H-Bonder
by Darryl B McConnell 5 minutes readWhen analyzing a drug binding pocket it is important to assess which amino acid…
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What to do with waters in the binding pocket of proteins is a conundrum…
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Key ConceptTheory
In Drug Design Two Thirds of H-bonds are Weak
by Darryl B McConnell 4 minutes readMedicinal chemists spend a lot of time thinking about how to make protein-ligand interactions…
