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How Big Are Your MedChem Atoms

07/10/2024

Chemical Space is Big, Really Big.

09/01/2024

Who´s to blame for octanol

08/01/2024

The Rule of Two

25/12/2023

Which Amino Acid is the Strongest H-Bonder

16/08/2023

What to do with the HIV Protease Flap Water

17/06/2023

In Drug Design Two Thirds of H-bonds are Weak

04/06/2023

The Six Molecular Interactions

18/03/2023

How to Make a Small Molecule Drug

05/02/2023

Apple Trees & SGLT2

28/01/2023

Latest Posts

Introductory

About McConnell’s MedChem

by Darryl B McConnell 27/01/2023
by Darryl B McConnell 27/01/2023 3 minutes read

In preparing my first medicinal chemistry course at the University of Vienna I wanted…

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Categories

  • Big Picture (1)
  • Finding (2)
  • Historical (1)
  • Introductory (6)
  • Key Concept (6)
  • Optimization (1)
  • Stories (2)
  • Theory (1)

Popular Posts

  • 1

    Which Amino Acid is the Strongest H-Bonder

    16/08/2023
  • 2

    Apple Trees & SGLT2

    28/01/2023
  • 3

    The Six Molecular Interactions

    18/03/2023
  • 4

    How to Make a Small Molecule Drug

    05/02/2023
  • 5

    In Drug Design Two Thirds of H-bonds are Weak

    04/06/2023

Recent Comments

  • http://Darryl%20B%20McConnell
    Darryl B McConnell

    Thanks Marcus and congratulations on pushing the exploration of chemical space together with the…

  • http://marcus
    marcus

    Beautifully outlined, as always, Darryl. Thanks very much. For those of you who are…

  • http://Darryl%20B%20McConnell
    Darryl B McConnell

    Thanks for the correction. I removed the company names from the post to avoid…

  • http://Darryl
    Darryl

    No I don't think so. As HBDs differ in strength a simple fudge factor…

  • http://Darryl
    Darryl

    Thanks! The current oral, clinical PROTACs are Rule of 2 compliant. I’ll do a…

  • http://Dchen
    Dchen

    Appreciate your writings. Is there a factor that can be developed to adjust the…

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About McConnell’s Medchem

McConnell’s Medchem is personal compendium of  what I think is important in medicinal chemistry with lots of graphics to simplify and illustrate.

 

Popular Posts

  • 1

    Which Amino Acid is the Strongest H-Bonder

    16/08/2023
  • 2

    Apple Trees & SGLT2

    28/01/2023
  • 3

    The Six Molecular Interactions

    18/03/2023

Editor’s Picks

  • How Big Are Your MedChem Atoms

    07/10/2024
  • Chemical Space is Big, Really Big.

    09/01/2024
  • Who´s to blame for octanol

    08/01/2024
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McConnellsMedchem
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McConnellsMedchem
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©2023 - All Right Reserved. Designed and Developed by Darryl B. McConnell